Pharmacological Effects Motrin:
Motrin NSAIDs, has analgesic, antipyretic and anti-inflammatory effect due to non-selective blockade TSOG1 and TSOG2 and exert an inhibitory effect on the synthesis of Pg. Analgesic effect is most pronounced at the pains of an inflammatory nature. Like all NSAIDs, ibuprofen exhibits antiplatelet activity.
Indications Motrin:
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, osteochondrosis, neuralgic amyotrophy (illness Personeydzha-Turner), arthritis in SLE (as part of adjuvant therapy), gouty arthritis (with an acute attack of gout preferred fast-dosage forms) , ankylosing spondylitis (ankylosing spondylitis). Pain syndrome: myalgia, arthralgia, ossalgiya, arthritis, sciatica, migraine, headache (including during the menstrual syndrome), and tooth pain, oncological diseases, neuralgia, tendonitis, tenosynovitis, bursitis, neuralgic amyotrophy (illness Personeydzha-Turner) , post-traumatic and postoperative pain accompanied by inflammation. Algomenorrhea, the inflammatory process in the pelvis, including adnexitis, childbirth (as analgesic and tokoliticheskogo means). Febrile syndrome with “cold” and infectious diseases.
Contraindications Motrin:
Hypersensitivity, erosive and ulcerative diseases of the digestive tract (including gastric ulcer and 12 duodenal ulcer in acute ulcerative colitis, peptic ulcer, Crohn’s disease – ulcerative colitis), “Aspirin” asthma, blood coagulation disorders (in including hemophilia, the lengthening of bleeding time, bleeding tendency, bleeding diathesis), pregnancy, laktatsii.C caution. Cirrhosis of the liver with portal hypertension, hyperbilirubinemia, peptic ulcer and 12 duodenal ulcer (history), gastritis, enteritis, colitis, liver and / or renal failure, nephrotic syndrome, heart failure, hypertension, blood disease of unknown etiology (leukopenia and anemia ), children’s age (for the tablet forms – up to 12 years, 6 months – for a suspension for oral administration). Children 6-12 months prescribe only on doctor’s advice.
Side effects Motrin:
From the digestive system: NSAID gastropathy (nausea, vomiting, abdominal pain, heartburn, decreased appetite, diarrhea, flatulence, pain and discomfort in the epigastric region), ulceration of the mucous membrane digestive tract (in some cases are complicated by perforation and hemorrhage); irritation dryness of the oral mucosa or mouth pain, ulceration of the mucous membrane of the gums, canker sores, pancreatitis, constipation, hepatitis. With the respiratory system: dyspnea, bronchospasm. From the senses: hearing loss, ringing or tinnitus, reversible toxic optic neuritis, blurred vision or double vision, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic genesis), scotoma. The nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rare – aseptic meningitis (usually in patients with autoimmune diseases). From the SSA: the development or worsening heart failure, tachycardia, increased blood pressure. With the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis. Allergic reactions: skin rash (usually erythematous, rash), pruritus, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome) , eosinophilia, and allergic rhinitis. For part of the blood: anemia (including hemolytic anemia, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia. Other: increased sweating. The risk of developing mucosal ulcerations gastrointestinal bleeding (gastrointestinal, gum, uterus, haemorrhoid), visual impairment (disturbance of color vision, scotoma, amblyopia) increases with prolonged use in large dozah.Peredozirovka. Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest. Treatment: gastric lavage (only one hour after ingestion), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of CBS, AP).
Dosage and administration Motrin:
Inside, after a meal. Adults: for osteoarthritis, psoriatic arthritis and ankylosing spondylitis – at 400-600 mg 3-4 times a day. In rheumatoid arthritis – 800 mg 3 times a day, with soft tissue injuries, sprains – 1.6-2.4 g / day in divided doses. When algodismenoree – 400 mg 3-4 times a day, with moderate pain syndrome – 1.2 g / day. Children older than 12 years of the initial dose – 150-300 mg 3 times daily, maximum dose – 1 g, then – 100 mg 3 times a day, with juvenile rheumatoid arthritis – 30-40 mg / kg / day in divided doses. To reduce body temperature 39.2 grad.S and above – 10 mg / kg / day, below the 39.2 grad.S – 5 mg / kg / day. Oral suspension – 5-10 mg / kg 3 times a day: for children aged 6-12 months (only by prescription) – an average of 50 mg 3-4 times daily, 1-3 years – 100 mg 3 times daily, 4-6 years – 150 mg 3 times daily, 7-9 years – 200 mg 3 times daily, 10-12 years – 300 mg 3 times a day. With feverish syndrome after immunization – 50 mg, if necessary after 6 h of re-admission to the same dose, the maximum daily dose – 100 mg.
Special instructions Motrin:
During treatment is necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys. When symptoms of gastropathy shows a carefully monitored, including an esophagogastroduodenoscopy, a blood test to the definition of Hb, hematocrit, and fecal occult blood. To prevent the development of NSAID-gastropathy recommended to combine with drugs PgE (misoprostol). If necessary, the definition of 17-ketosteroids drug should be discontinued for 48 h before the study. Patients should refrain from all activities that require special attention, rapid mental and motor responses. During the period of treatment is not recommended acceptance of ethanol.
Interaction Motrin:
Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators (including BCCI, and ACE inhibitors), natriuretic and diuretic – furosemide and hydrochlorothiazide. Urikozuricheskih reduces the effectiveness of drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic complications), ulcerogenic action with bleeding ISS and corticosteroids, colchicine, estrogens, ethanol enhances the effect of oral hypoglycemic drugs and insulin. Antacids and kolestiramin reduce the absorption of ibuprofen. Increases blood levels of digoxin, drugs Li + and methotrexate. Caffeine increases the analgesic effect. While appointing ibuprofen reduces inflammatory and antiplatelet effect of ASA (may increase the incidence of acute coronary insufficiency in patients receiving antiplatelet as a means of low-dose ASA after starting ibuprofen). In the appointment of anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase) also increase the risk of bleeding. Tsefamandol, tsefaperazon, tsefotetan, valproic acid, plikamitsin increase the incidence of gipoprotrombinemiey. Myelotoxic drugs increase gematotoksichnosti manifestations of the drug. Cyclosporine and preparations Au enhances the effect of ibuprofen on the synthesis of Pg in the kidney, which is manifested increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion, reduce excretion and increase plasma concentration of ibuprofen.
